NervAlign® Nerve Cuff
The NervAlign® Nerve Cuff is a decellularized porcine pericardium membrane designed to provide non-constricting protection for peripheral nerve repairs.
Its ultra-thin, pliable construction allows it to be easily trimmed and affixed intraoperatively, conforming to the repair site without restricting the nerve.
Key Features
The Critical Difference
The NervAlign Nerve Cuff is manufactured using the eCOO® method – a proprietary advanced manufacturing process for cleaning and decellularizing tissue. The eCOO® method removes unwanted immunogenic material using supercritical carbon dioxide (scCO2). *
Beyond Gas, Beyond Liquid
When heated and pressurized beyond its critical point, carbon dioxide becomes a supercritical fluid which diffuses like a gas and cleans like a liquid. Its unique properties are ideal for cleaning and decellularizing tissue without altering its structure.
NervAlign Nerve Cuff processed using eCOO® method
Typical porcine small intestine submucosal (SIS) tissue
Yields a collagen membrane that is clean and pliable while maintaining its native structure
Dark blue stain indicates residual contaminating native nuclei
Emerging Clinical Data
Recent real-world data presented at ACFAS 2025 shows the potential benefits of the NervAlign Nerve Cuff in clinical practice.2
Average follow-up time was 9.25 months after Nerve Cuff application. Pain scores measured using Visual Analogue Scale.
Indications for Use
The NervAlign Nerve Cuff is indicated for the repair of peripheral nerves where there is no gap, or where gap closure is achieved by flexion of the extremity
Ordering Information
Key Features
NA-NC1010
NA-NC2030
NA-NC3040
Dimensions (length × width)
10 x 10 mm
20 x 30mm
30 x 40mm
References
(1) Rhodes, D.; Chick, J. RN-SM-MRK-015 NervAlign White Paper, 2025.
(2) Namany, N.; Peasley, K.; Adams, W. Efficacy of a Porcine Pericardium Nerve Wrap in Peripheral Nerve Surgery, 2025. https://www.acfas.org/admin/ACFAS/media/PDF/Abstract-Report-1.pdf (accessed 2025-08-28).
*eCOO is a registered trademark of Leader Biomedical Ltd